Ron Perlman returns to voice the narrator in Fallout: New Vegas, a role he has played in every major Fallout game to date. Matthew Perry plays Benny, a smooth-talking, two faced gangster, and Wayne Newton takes on the role as "Mr. New Vegas," the radio DJ of the Mojave Wasteland.

Three celebrities take on roles as playable companions in Fallout: New Vegas: Danny Trejo is Raul the Ghoul, a mechanic and former gunslinger; Zach Levi is Arcade, a member of the Followers of the Apocalypse who hides a mysterious past, and Felicia Day is Veronica, a sarcastic Brotherhood of Steel scribe.

The epic cast continues with Kris Kristofferson as Chief Hanlon, a grizzled soldier at the end of his career, and Rene Auberjonois as the enigmatic and reclusive Mr. House. Michael Dorn reprises his role as Marcus, an intelligent super mutant, who was last seen in 1998’s Fallout® 2; John Doman is Caesar, the charismatic and powerful dictator at the head of Caesar’s Legion. William Sadler plays Victor, a friendly robot with the personality of an old fashioned cowboy.